DNA
ABL1 | ABL2 | ACVR1 | ACVR1B | AKT1 | AKT2 | AKT3 | ALK | ALOX12B | ANKRD11 | ANKRD26 | APC | AR | ARAF | ARFRP1 | ARID1A | ARID1B | ARID2 | ARID5B | ASXL1 |
ASXL2 | ATM | ATR | ATRX | AURKA | AURKB | AXIN1 | AXIN2 | AXL | B2M | BAP1 | BARD1 | BBC3 | BCL10 | BCL2 | BCL2L1 | BCL2L11 | BCL2L2 | BCL6 | BCOR |
BCORL1 | BCR | BIRC3 | BLM | BMPR1A | BRAF | BRCA1 | BRCA2 | BRD4 | BRIP1 | BTG1 | BTK | C11orf30 | CALR | CARD11 | CASP8 | CBFB | CBL | CCND1 | CCND2 |
CCND3 | CCNE1 | CD274 | CD276 | CD74 | CD79A | CD79B | CDC73 | CDH1 | CDK12 | CDK4 | CDK6 | CDK8 | CDKN1A | CDKN1B | CDKN2A | CDKN2B | CDKN2C | CEBPA | CENPA |
CHD2 | CHD4 | CHEK1 | CHEK2 | CIC | CREBBP | CRKL | CRLF2 | CSF1R | CSF3R | CSNK1A1 | CTCF | CTLA4 | CTNNA1 | CTNNB1 | CUL3 | CUX1 | CXCR4 | CYLD | DAXX |
DCUN1D1 | DDR2 | DDX41 | DHX15 | DICER1 | DIS3 | DNAJB1 | DNMT1 | DNMT3A | DNMT3B | DOT1L | E2F3 | EED | EGFL7 | EGFR | EIF1AX | EIF4A2 | EIF4E | EML4 | EP300 |
EPCAM | EPHA3 | EPHA5 | EPHA7 | EPHB1 | ERBB2 | ERBB3 | ERBB4 | ERCC1 | ERCC2 | ERCC3 | ERCC4 | ERCC5 | ERG | ERRFI1 | ESR1 | ETS1 | ETV1 | ETV4 | ETV5 |
ETV6 | EWSR1 | EZH2 | FAM123B | FAM175A | FAM46C | FANCA | FANCC | FANCD2 | FANCE | FANCF | FANCG | FANCI | FANCL | FAS | FAT1 | FBXW7 | FGF1 | FGF10 | FGF14 |
FGF19 | FGF2 | FGF23 | FGF3 | FGF4 | FGF5 | FGF6 | FGF7 | FGF8 | FGF9 | FGFR1 | FGFR2 | FGFR3 | FGFR4 | FH | FLCN | FLI1 | FLT1 | FLT3 | FLT4 |
FOXA1 | FOXL2 | FOXO1 | FOXP1 | FRS2 | FUBP1 | FYN | GABRA6 | GATA1 | GATA2 | GATA3 | GATA4 | GATA6 | GEN1 | GID4 | GLI1 | GNA11 | GNA13 | GNAQ | GNAS |
GPR124 | GPS2 | GREM1 | GRIN2A | GRM3 | GSK3B | H3F3A | H3F3B | H3F3C | HGF | HIST1H1C | HIST1H2BD | HIST1H3A | HIST1H3B | HIST1H3C | HIST1H3D | HIST1H3E | HIST1H3F | HIST1H3G | HIST1H3H |
HIST1H3I | HIST1H3J | HIST2H3A | HIST2H3C | HIST2H3D | HIST3H3 | HLA-A | HLA-B | HLA-C | HNF1A | HNRNPK | HOXB13 | HRAS | HSD3B1 | HSP90AA1 | ICOSLG | ID3 | IDH1 | IDH2 | IFNGR1 |
IGF1 | IGF1R | IGF2 | IKBKE | IKZF1 | IL10 | IL7R | INHA | INHBA | INPP4A | INPP4B | INSR | IRF2 | IRF4 | IRS1 | IRS2 | JAK1 | JAK2 | JAK3 | JUN |
KAT6A | KDM5A | KDM5C | KDM6A | KDR | KEAP1 | KEL | KIF5B | KIT | KLF4 | KLHL6 | KMT2B | KMT2C | KMT2D | KRAS | LAMP1 | LATS1 | LATS2 | LMO1 | LRP1B |
LYN | LZTR1 | MAGI2 | MALT1 | MAP2K1 | MAP2K2 | MAP2K4 | MAP3K1 | MAP3K13 | MAP3K14 | MAP3K4 | MAPK1 | MAPK3 | MAX | MCL1 | MDC1 | MDM2 | MDM4 | MED12 | MEF2B |
MEN1 | MET | MGA | MITF | MKNK1 | MLH1 | MLL | MLLT3 | MPL | MRE11A | MSH2 | MSH3 | MSH6 | MSI1 | MSI2 | MST1 | MST1R | MTAP | MTOR | MUTYH |
MYB | MYC | MYCL | MYCL1 | MYCN | MYD88 | MYOD1 | NAB2 | NBN | NCOA3 | NCOR1 | NEGR1 | NF1 | NF2 | NFE2L2 | NFKBIA | NKX2-1 | NKX3-1 | NOTCH1 | NOTCH2 |
NOTCH3 | NOTCH4 | NPM1 | NRAS | NRG1 | NSD1 | NT5C2 | NTHL1 | NTRK1 | NTRK2 | NTRK3 | NUF2 | NUP93 | NUTM1 | P2RY8 | PAK1 | PAK3 | PAK7 | PALB2 | PARK2 |
PARP1 | PARP2 | PARP3 | PAX3 | PAX5 | PAX7 | PAX8 | PBRM1 | PDCD1 | PDCD1LG2 | PDGFRA | PDGFRB | PDK1 | PDPK1 | PGR | PHF6 | PHOX2B | PIK3C2B | PIK3C2G | PIK3C3 |
PIK3CA | PIK3CB | PIK3CD | PIK3CG | PIK3R1 | PIK3R2 | PIK3R3 | PIM1 | PLCG2 | PLK2 | PMAIP1 | PMS1 | PMS2 | PNRC1 | POLD1 | POLE | PPARG | PPM1D | PPP2R1A | PPP2R2A |
PPP4R2 | PPP6C | PRDM1 | PRDM14 | PREX2 | PRKAR1A | PRKCI | PRKD1 | PRKDC | PRSS8 | PTCH1 | PTEN | PTP4A1 | PTPN11 | PTPRD | PTPRO | PTPRS | PTPRT | QKI | RAB35 |
RAC1 | RAC2 | RAD21 | RAD50 | RAD51 | RAD51B | RAD51C | RAD51D | RAD52 | RAD54L | RAF1 | RANBP2 | RARA | RASA1 | RB1 | RBM10 | RECQL | RECQL4 | REL | RET |
RFWD2 | RHEB | RHOA | RICTOR | RIT1 | RNF43 | ROS1 | RPS6KA4 | RPS6KB1 | RPS6KB2 | RPTOR | RRAGC | RRAS | RRAS2 | RTEL1 | RUNX1 | RUNX1T1 | RXRA | RYBP | SDHA |
SDHAF2 | SDHB | SDHC | SDHD | SESN1 | SESN2 | SESN3 | SETBP1 | SETD2 | SETD8 | SF3B1 | SGK1 | SH2B3 | SH2D1A | SHOC2 | SHQ1 | SLIT2 | SLX4 | SMAD2 | SMAD3 |
SMAD4 | SMARCA4 | SMARCB1 | SMARCD1 | SMC1A | SMC3 | SMO | SMYD3 | SNCAIP | SOCS1 | SOS1 | SOX10 | SOX17 | SOX2 | SOX9 | SPEN | SPOP | SPRED1 | SPTA1 | SRC |
SRSF2 | STAG1 | STAG2 | STAT3 | STAT4 | STAT5A | STAT5B | STK11 | STK19 | STK40 | SUFU | SUZ12 | SYK | TAF1 | TAP1 | TAP2 | TBX3 | TCEB1 | TCF3 | TCF7L2 |
TEK | TERC | TERT | TET1 | TET2 | TFE3 | TFRC | TGFBR1 | TGFBR2 | TIPARP | TMEM127 | TMPRSS2 | TNFAIP3 | TNFRSF14 | TOP1 | TOP2A | TP53 | TP53BP1 | TP63 | TRAF2 |
TRAF7 | TSC1 | TSC2 | TSHR | TYRO3 | U2AF1 | UPF1 | VEGFA | VHL | VTCN1 | WHSC1 | WHSC1L1 | WISP3 | WT1 | WWTR1 | XIAP | XPO1 | XRCC2 | YAP1 | YES1 |
ZBTB2 | ZBTB7A | ZFHX3 | ZNF217 | ZNF703 | ZRSR2 | + 185 InDels/MSI |
Method: Next Generation Sequencing (NGS)
Sample Type: Tissue, Blood (Liquid Biopsy Tube)
Results Time: 30 Days
Sensitivity: 99%
Description: 566 Genes + TMB (Tumor Mutational Burden) + MSI
COMPREHENSIVE CANCER PANEL
✓ Paraffin Block ✓ Liquid Biopsy
COMPREHENSIVE CANCER PANEL
In some genetic changes that are detected, major drugs are highly effective regardless of the type of cancer. This treatment approach is called tumor agnostic therapy. The genetic changes identified for tumor agnostic therapies approved by the US drug agency are ret, ntrk, braf. Microsatellite instability is also one of the tumor agnostic markers. HER2 expression and alk rearrangement, which are close to being approved recently, are also tumor agnostic candidates. In addition, tumor mutation burden calculation called TMB can also predict whether immunotherapies will be beneficial or not. For this reason, comprehensive genetic analyses are recommended for some cancer types at the very beginning of treatment and for others in case of resistance to standard therapies.